Antisense modulation of AKT-3 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Lex M. Cowsert, Richard A. Roth
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Akt-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Akt-3. Methods of using these compounds for modulation of Akt-3 expression and for treatment of diseases associated with expression of Akt-3 are provided.
Claims14
An antisense compound up to 30 nucleobases in length targeted to a nucleic acid molecule encoding human Akt-3, wherein said antisense compound inhibits the expression of human Akt-3 and wherein said antisense compound comprises at least an 8 nucleobase portion of SEQ ID NO:
- 13, 14, 18, 20, 22, 27, 29, 34, 37, 38, 40, 41, 42, 43, 47, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 75, 76, 77, 78, 79, 80, 81, 83, 84, 85, 86, 88, 89 or 91.
Dependencies are inferred from the claim text.