Electrodialysis methods for purification and recovery of gluconic acid derivatives
AssigneeThe Electrosynthesis Company, Inc.
InventorsJ. David Genders, Ram Gopal, Dan M. Hartsough, Peter M. Kendall, William J. Long, Duane J. Mazur, Guillermo D. Zappi
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Abstract
A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic acid derivative and/or salt thereof to electrodialysis thereby purifying and concentrating the gluconic acid derivative.
Claims12
A process for preparing a purified and concentrated gluconic acid derivative, the process comprising:
- a) providing a non-viable fermentation medium having a pH less than 3.5 comprising at least the gluconic acid derivative or a salt thereof, the gluconic acid derivative selected from the group consisting of 2,4, keto-D-gluconic acid, 2,5, diketo-D-gluconic acid, idonic acid, 2-keto-L-gulonic acid (KLG), vanillic acid and ascorbic acid;
- and
- b) removing the gluconic acid derivative from the non-viable fermentation medium by electrodialysis thereby providing a concentrated solution comprising at least the gluconic acid derivative and a non-viable fermentation waste stream having neutrals therein to be removed from the system.
A process for preparing a purified and concentrated gluconic acid derivative comprising the steps of:
- a) providing a non-viable fermentation medium having a pH less than 3.5 comprising at least the gluconic acid derivative selected from the group consisting of 2,4, keto-D-gluconic acid, 2,5, diketo-D-gluconic acid, idonic acid, 2-keto-L-gulonic acid (KLG), vanillic acid and ascorbic acid, an inorganic impurity and a neutral;
- b) removing the gluconic acid derivative and inorganic impurity from the non-viable fermentation medium by electrodialysis thereby providing a concentrated acidified aqueous solution comprising at least the gluconic acid derivative and inorganic impurity, and a waste stream comprising a spent non-viable fermentation waste stream containing unionized neutrals and which is essentially depleted of the gluconic acid derivative;
- c) separating the inorganic impurity from the concentrated acidified aqueous solution thereby providing a purified and concentrated aqueous solution of the gluconic acid derivative;
- and
- d) recovering the gluconic acid derivative from the purified and concentrated aqueous solution.
Dependencies are inferred from the claim text.