Polynucleotides and polypeptides belonging to the uncoupling proteins family
AssigneeSmithKline Beecham Corporation
InventorsLee James Beeley, Kelly Paine, Robert James Godden
Life of this patent
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Abstract
HNFCW60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFCW60 polypeptides and polynucleotides in the design of protocols for the treatment of obesity, diabetes, hyperlipademia and body weight disorder, among others, and diagnostic assays for such conditions.
Claims12
An isolated polynucleotide comprising the polynucleotide sequence set forth in SEQ ID NO:
- 1.
An isolated polynucleotide which is fully complementary to
- (a) a nucleotide sequence comprising the polynucleotide sequence of SEQ ID NO:1;
- or
- (b) a nucleotide sequence consisting of the polynucleotide sequence of SEQ ID NO:1.
An isolated polynucleotide comprising the polynucleotide sequence of SEQ ID NO:3.
An isolated polynucleotide encoding the polypeptide sequence of SEQ ID NO:6.
An isolated polynucleotide comprising the polynucleotide sequence set forth in SEQ ID NO:
- 5.
An isolated polynucleotide which is fully complementary to
- (a) a nucleotide sequence comprising the polynucleotide sequence of SEQ ID NO:3;
- (b) a nucleotide sequence consisting of the polynucleotide sequence of SEQ ID NO:3;
- (c) a nucleotide sequence comprising the polynucleotide sequence of SEQ ID NO:5;
- or
- (d) a nucleotide sequence consisting of the polynucleotide sequence of SEQ ID NO:5.
An expression system comprising a polynucleotide encoding SEQ ID NO:2, wherein said expression system is capable of producing a polypeptide comprising the amino acid sequence of SEQ ID NO:2 when said expression system is present in a compatible host cell.
Dependencies are inferred from the claim text.