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Assignee3M Innovative Properties Company
InventorKestutis J. Tautvydas
Estimating the term…
Microbial spores having increased sensitivity to sterilants are provided. An additive such as a dipeptide, oligosaccharide, and/or polyhydroxyalcohols are added to the spores wherein the additive is bound to sterilant-sensitive sites in the spores. The additive increases sensitivity of the spores to a sterilant. More than one additive can be utilized to alter the sensitivity of the spores to a sterilant. Biological indicators comprising the microbial spores and a solid support are also disclosed and those spores having a dipeptide specifically bound to sterilant-sensitive sites in the spores have an altered sensitivity to a sterilant. Furthermore, a method is disclosed for altering the sensitivity of microbial spores to a sterilant comprising drying the spores at a temperature between 35° C. and 55° C. in a liquid composition having an amount of the additive therein.
Microbial spores comprising an additive specifically bound to sterilant-sensitive sites in said spores, wherein said additive increases sensitivity of said spores to a sterilant.
Microbial spores comprising a dipeptide specifically bound to sterilant-sensitive sites in said spores, said dipeptide altering sensitivity of said spores to a sterilant.
Microbial spores comprising two or more additives specifically bound to sterilant-sensitive sites in said spores, said additives increasing sensitivity of said spores to a sterilant.
A method for increasing the sensitivity of microbial spores to a sterilant, said method comprising drying said spores in a liquid composition comprising an additive in an amount effective to increase sensitivity of microbial spores to a sterilant when said additive is specifically bound to sterilant-sensitive sites in said spores, wherein drying said spores occurs at a temperature between about 35° C. and about 55° C.
A biological indicator comprising microbial spores and a solid support to which said spores are attached, said spores comprising two or more additives specifically bound to sterilant-sensitive sites in said spores, said additives increasing sensitivity of said spores to a sterilant.
A biological indicator comprising microbial spores and a solid support to which said spores are attached, said spores comprising a dipeptide specifically bound to sterilant-sensitive sites in said spores, said dipeptide altering sensitivity of said spores to a sterilant.
Dependencies are inferred from the claim text.