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US 6,187,545 B1Granted
Antisense modulation of pepck-cytosolic expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsRobert McKay, Madeline M. Butler, Jacqueline Wyatt, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of PEPCK-cytosolic. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PEPCK-cytosolic. Methods of using these compounds for modulation of PEPCK-cytosolic expression and for treatment of diseases associated with expression of PEPCK-cytosolic are provided.
Claims10
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 18, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 32, 33, 34, 35, 36, 37, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 60, 62, 65, 67, 68, 69, 70, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 86, 87, 88, 94, 95, 108, 110, 113, 114, 121, 125, 140, 145, 157, 169, 173, 174 or 176 which inhibits the expression of PEPCK-cytosolic.
Dependencies are inferred from the claim text.