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AssigneeThomas Jefferson University
InventorsDavid Weinberg, Scott A. Waldman, Michael T. Barber, Sanjoy Biswas
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Conjugated compounds which comprises an CCK A receptor binding moiety and a radiostable active moiety are disclosed. Pharmaceutical compositions comprising conjugated compound which comprises an CCK A receptor binding moiety and a radiostable active moiety or an CCK A receptor binding moiety and a radioactive active moiety are disclosed. Methods of treating an individual suspected of suffering from pancreatic cancer are disclosed. Methods of radioimaging pancreatic cancer cells are disclosed. In vitro methods, kits and reagents are disclosed for determining whether or not an individual has pancreatic cancer cells, for determining whether tumor cells are pancreatic in origin and for analyzing tissue samples to evaluate the extent of metastasis of pancreatic tumor cells.
An in vitro method of determining whether a human individual has pancreatic cancer comprising the step of analyzing a sample of pancreatic tissue or fluid from a human to determine whether said sample contains mRNA that encodes CCK A receptor protein wherein the presence of mRNA that encodes CCK A receptor protein in the sample indicates that the human has pancreatic cancer.
An in vitro method of determining whether a human tumor cell is a human pancreatic tumor cell comprising detecting the presence of mRNA that encodes CCK A receptor protein in the human tumor cell, wherein the presence of mRNA that encodes CCK A receptor protein in the human tumor cell indicates that the human tumor cell may be a human pancreatic tumor cell.
An in vitro method of determining whether a human who has been diagnosed as having or who is suspected of having pancreatic cancer has metastatic pancreatic cancer comprising the step of analyzing a sample of blood, lymph tissue or lymph fluid from the human to determine whether the sample contains mRNA that encodes CCK A receptor protein, wherein the presence of mRNA that encodes CCK A receptor protein in the sample from a human who has been diagnosed as having or who is suspected of having pancreatic cancer indicates that the human has metastatic pancreatic cancer.
Dependencies are inferred from the claim text.