Carrier matrix for integrated microanalysis systems, method for the production thereof and use of the same
AssigneePharmacia Biotech AB
InventorsThomas Laurell, Johan Drott, Lars Rosengren, Kjell Lindström
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Abstract
A silicon-based carrier matrix having a high ratio of surface area to volume is intended for use in integrated microanalysis systems. The carrier matrix comprises at least one layer of microporous silicon on a body of monocrystalline silicon. A method for producing the carrier matrix comprises electrochemical etching of a body of monocrystalline silicon, thereby to form at least one layer of microporous silicon on this body. The use of the carrier matrix for chemical sensors in integrated microanalysis systems, as well as in various sorts of chromatography, is also disclosed.
Claims30
A silicon-based carrier matrix having an increase in ratio of surface area to volume by a factor of at least 30, as compared with a smooth silicon surface, for integrated microanalysis systems, characterized in that it comprises at least one layer of microporous silicon on a body of monocrystalline silicon.
A silicon-based carrier matrix which exhibits an increase in enzymatic activity by a factor of at least 30 when a reagent is immobilized thereon, as compared with a smooth silicon surface having said reagent immobilized thereon, for integrated microanalysis systems, characterized in that it comprises at least one layer of microporous silicon on a body of monocrystalline silicon.
A silicon-based carrier matrix which exhibits an increase in chemical activity by a factor of at least 30 when a reagent is immobilized thereon, as compared with a smooth silicon surface having said reagent immobilized thereon, for integrated microanalysis systems, characterized in that it comprises at least one layer of microporous silicon on a body of monocrystalline silicon.
A method for producing a silicon-based carrier matrix having an increase in ratio of surface area to volume by a factor of at least 30, as compared with a smooth silicon surface, for integrated microanalysis systems, comprising:
- electrochemical etching of a body of monocrystalline silicon for forming at least one layer of microporous silicon on said body.
An integrated microanalysis method, comprising:
- contacting a sample to be tested, in an integrated microanalysis system, with a chemical sensor comprising a silicon-based carrier matrix having an increase in ratio of surface area to volume by a factor of at least 30, as compared with a smooth silicon surface, wherein said carrier matrix comprises at least one layer of microporous silicon on a body of monocrystalline silicon;
- and
- measuring a chemical property of said sample.
Dependencies are inferred from the claim text.