Powdered pharmaceutical formulations having improved dispersibility
AssigneeInhale Therapeutic Systems
InventorsMohammed Eljamal, John S. Patton, Linda C. Foster, Robert M. Platz
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Abstract
Dispersibility of a respirable powder, administrable by inhalation, is increased by including a pharmaceutically acceptable water-soluble polypeptide.
Claims17
A spray-dried dispersible powdered composition suitable for inhalation by a human subject, comprising:
- (a) a therapeutically effective amount of an active agent suitable for treating a condition in said subject by inhalation;
- (b) a pharmaceutically-acceptable excipient selected from the group consisting of carbohydrates, amino acids, and mixtures thereof, wherein said excipient is present in an amount sufficient to uniformly distribute the active agent throughout the composition, and
- (c) about 1% by weight to about 15% by weight of a dispersibility-enhancing, physiologically-acceptable, water-soluble polypeptide, whereby the presence of said polypeptide in the composition is effective to increase the dispersibility of the composition over the dispersibility of the composition in the absence of said polypeptide.
A method for treating a condition in a human being that is susceptible to treatment by inhalation, which method comprises inhaling a spray-dried aerosolized composition comprising (a) a therapeutically effective amount of an active agent suitable for treating a condition in the subject by inhalation;
- (b) about 1% by weight to about 15% by weight of a dispersibility-enhancing amount of physiologically-acceptable, water-soluble polypeptide, and (c) a pharmaceutically-acceptable excipient that comprises a carbohydrate, amino acid or mixture thereof, which excipient is present in an amount sufficient to uniformly distribute the active agent throughout the composition.
In a dispersible powdered composition that is suitable for inhalation by a human subject and that comprises a pharmaceutically acceptable excipient and an active agent suitable for treating a condition in the subject by inhalation therapy, the improvement wherein the dispersible powdered composition is spray-dried and also includes about 1% by weight to about 15% by weight of a dispersibility-enhancing, psychologically-acceptable, water-soluble polypeptide.
Dependencies are inferred from the claim text.