Solid pharmaceutical composition comprising an excipient capable of binding water
AssigneeAkzo Nobel N.V.
InventorsPieter de Haan, Henrika Gerardina Maria Poels-Janssen
Life of this patent
Estimating the term…
Abstract
The invention concerns a solid pharmaceutical composition comprising less than 7% by weight of an oil or oily substance, a low dosage active ingredient, and a water insoluble non-cross-linked polymeric excipient capable of binding water and having a mean particle size greater than 150 μm. The composition can be obtained by a simple procedure comprising mixing the water insoluble non-cross-linked polymeric excipient capable of binding water and the active ingredient, which is dissolved or dispersed in an oil or an oily substance, in an aqueous dispersion thereof, or in water.
Claims11
A solid pharmaceutical composition comprising at least one solvent or dispersant selected from the group consisting of an oil, an oily substance, an aqueous dispersion of an oil or oily substance, and water, a low dosage active ingredient, and a water insoluble non-cross-linked polymeric excipient that binds water and has a particle size distribution wherein at least 50% of the particles by volume have a diameter of from 150μ to 200μ, wherein the oil, oily substance or dispersion is present in an amount by which the oil or oily substance contributes from 0% to 7% by weight of the pharmaceutical composition and wherein any water present is present in an amount by which the weight ratio of polymeric excipient to water is greater than 5:1.
Dependencies are inferred from the claim text.