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US 6,187,335 B1Granted
Polymerizable fatty acids, phospholipids and polymerized liposomes therefrom
AssigneeOrasomal Technologies, Inc.
InventorsRobert N Brey, Likan Liang
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Abstract
The invention relates to an oral drug delivery system which delivers biologically active substances to the mucosal tissue of the intestine utilizing novel polymerized liposomes. Novel polymerizable fatty acids having a polymerizable group, a surfactant group, and a functional group, and optionally coupled to ligands which target mucosal tissue in the intestine are disclosed. Novel negatively charged polymerizable lipids which have phosphatidyl inositol (PI), phosphatidyl glycerol (PG) or phosphatidyl serine (PS) groups on a polymerizable backbone are also described.
Claims8
A polymerizable compound of formula:
- R4—X—PEG—Y—B
- or a pharmaceutically acceptable salt thereof, wherein R4 is a lipophilic chain containing at least one polymerizable moiety;
- each of X and Y is independently a chemically stable bond or a linker moiety;
- and B is —O—C(O)—(CH2)pCO2H, C(O)NHR6, C(O)NH2, an aldehyde or NH2;
- wherein p is an integer from 0 to 12;
- R6 is a C, to C5 alkyl group;
- and PEG is a polyethylene glycol group having an average molecular weight of about 200 to about 2000 grams/mole.
4 more elements
Dependencies are inferred from the claim text.