US 6,187,331 B1Granted

Composition for prophylaxis and/or treatment of dry syndrome comprising vitamin D

AssigneeNew Vision Co., Ltd.

InventorsSeiji Itoh, Yasuo Ishii, Katsuhiko Mukai, Kiyoshi Kita

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Abstract

An ophthalmic composition for prophylaxis and/or treatment of keratoconjunctivitis sicca, which is locally administered to the eyes and which comprises, as an effective component, at least one member selected from the group consisting of vitamin D, active vitamin D, and active vitamin D analogues.

Claims12

Dependent claims

A method for preventing and/or treating keratoconjunctivitis sicca, which comprises administering locally to at least one eye of a patient in need of same, an amount of an ophthalmic composition effective to prevent and/or treat keratoconjunctivitis sicca,

wherein said ophthalmic composition comprises, as an effective component, at least one member selected from the group consisting of an ergocalciferol, a cholecalciferol, calcitriol, α-calcidol, calcifedol, 1α,24,25-trihydroxy vitamin D, 1β,25-dihydroxy vitamin D, 22-oxacalcitriol, calcipotriol and dihydrotachysterol, said composition further comprising an ophthalmically acceptable carrier, wherein said effective component is present in said composition in a concentration of 0.001-100 μg/ml, with a viscosity of 0.01-10 poise at room temperature.

Dependencies are inferred from the claim text.

Facts

Application: 09/575,987Filed 23 May 2000 · continuation
Priority: 10 Jun 1997
Granted: 13 Feb 2001
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/59
Medicinal preparations containing organic active ingredients: compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/592
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
A61K 31/593
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3

Family

Application08/872,052Parent of this continuation · filed 10 Jun 1997
US 6,187,331 B1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

Facts

Application

09/575,987Filed 23 May 2000 · continuation

Priority

10 Jun 1997

Granted

13 Feb 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/59
Medicinal preparations containing organic active ingredients: compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 31/592
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
A61K 31/593
Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems: 9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3