Controlled release delivery of peptide or protein
AssigneeScios, Inc.
InventorsYu-Chang John Wang, Bing Yang, Robert N. Jennings, Jr., Andrew A. Protter
Life of this patent
Estimating the term…
Abstract
Compositions and devices for the controlled release delivery of a peptide or protein drug are produced by dispersing a glassy matrix phase comprising the peptide or protein drug and a thermoprotectant in a bioerodable, biocompatible polymer at a temperature that is below the glass transition temperature of the glassy matrix phase and above the melting point of the polymer. The method and composition of the invention may be employed for the local delivery of angiogenic amounts of basic fibroblast growth factor or vascular endothelial growth factor.
Claims36
A composition for the controlled release of a peptide or protein comprising a biocompatible, bioerodable polymer having dispersed therein a glassy matrix phase comprising the peptide or protein and a thermoprotectant, said glassy matrix phase having a glass transition temperature above the melting point of the polymer.
A method for producing a composition for the controlled release delivery of a bioactive peptide or protein which comprises
- (a) dispersing a glassy matrix comprising the bioactive peptide or protein and a thermoprotectant in a biocompatible, bioerodable polymer at a temperature above the melting point of the polymer and below the glass transition temperature of the glassy matrix;
- and
- (b) cooling the dispersion to a temperature at which the polymer is a solid.
Dependencies are inferred from the claim text.