Cross-protective rotavirus vaccine
AssigneeUniversity of Massachusetts
InventorsJohn E. Herrmann, Shan Lu
Life of this patent
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Abstract
A method of producing an effective immune response in an animal against a first rotavirus, by (1) identifying an animal susceptible to or having a first rotavirus infection; and (2) administering to the animal an isolated VP6 polypeptide of a second rotavirus sufficient to produce an effective immune response against the first rotavirus, the second rotavirus capable of infecting a different species than the first rotavirus.
Claims27
A method of producing a protective immune response in a bird or mammal against a first rotavirus, the method comprising:
- identifying a bird or mammal susceptible to or having a first rotavirus infection;
- administering to the bird or mammal an isolated VP6 polypeptide of a second rotavirus sufficient to produce a protective immune response against the first rotavirus, the second rotavirus capable of infecting a different species than the first rotavirus.
A method of producing a protective immune response in a individual against a human rotavirus, the method comprising:
- identifying an individual susceptible to or having a human rotavirus infection;
- administering to the individual a DNA plasmid expression vector comprising a sequence encoding a VP6 polypeptide of a non-human rotavirus, the VP6 polypeptide expressed from the DNA plasmid in vivo being sufficient to produce a protective immune response in the individual against the human rotavirus.
A method of producing a protective immune response in a bird or mammal of a first species against a first rotavirus, the method comprising:
- identifying a bird or mammal of a first species susceptible to or having a first rotavirus infection;
- administering to the bird or mammal an isolated VP6 polypeptide of a second rotavirus sufficient to produce a protective immune response against the first rotavirus, the second rotavirus capable of infecting a second species different from the first species and incapable of infecting the first species.
Dependencies are inferred from the claim text.