Lysine decarboxylase inhibitors for the prevention and treatment of periodontal disease
AssigneeThe Board of Regents of the University of Oklahoma
InventorMartin Levine
Life of this patent
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Abstract
An agent, α-difluoromethyl lysine (DEML) or α-monofluoromethyl lysine (MFML), which inhibits activity of lysine decarboxylases produced by bacteria associated with periodontal tissues. Inhibition of the activity of such lysine decarboxylases can prophylactically and therapeutically treat periodontal diseases such as gingivitis and periodontitis. The agent may be incorporated into toothpastes, mouthwashes, irrigation solutions, tablets, periodontal treatment packs, or an adhesive paste or film coatings for applying to the teeth.
Claims12
A composition suitable for use in a patient whose oral flora includes plaque bacteria producing lysine decarboxylase to prevent or inhibit lysine decarboxylase activity as a prophylactic treatment to prevent or inhibit initial gingivitis or periodontitis or in patients afflicted with gingivitis or periodontitis for controlling or inhibiting the redevelopment of gingivitis or periodontitis comprising:
- an inhibitor of lysine decarboxylase;
- and
- a pharmaceutically acceptable carrier or vehicle selected from the group consisting of a periodontal pack, a mouthwash, a toothpaste, and an adhesive paste, adhesive gel or adhesive solution for forming a film or coating on the patient's teeth.
A toothpaste, comprising:
- an inhibitor of lysine decarboxylase in an effective concentration for inhibiting lysine decarboxylase in a patient whose oral flora includes plaque bacteria producing lysine decarboxylase to prevent or inhibit lysine decarboxylase activity, as a prophylactic treatment to prevent or inhibit initial gingivitis or periodontitis or in patients afflicted with gingivitis or periodontitis for controlling or inhibiting the redevelopment of gingivitis or periodontitis.
A composition for oral application directly to a patient's teeth, comprising:
- a periodontal adhesive;
- and
- an inhibitor of lysine decarboxylase in an effective concentration for inhibiting lysine decarboxylase in a patient whose oral flora includes plaque bacteria producing lysine decarboxylase to prevent or inhibit lysine decarboxylase activity, as a prophylactic treatment to prevent or inhibit initial gingivitis or periodontitis or in patients afflicted with gingivitis or periodontitis for controlling or inhibiting the redevelopment of gingivitis or periodontitis.
Dependencies are inferred from the claim text.