Tumor imaging agents, methods and kits
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, John W. Babich
Life of this patent
Estimating the term…
Abstract
The invention provides tumor imaging agents comprising a radionuclide in association with a nucleotide polyphosphate targeting molecule. Methods for using the tumor imaging agents and kits containing the tumor imaging agents or components suitable for production of the tumor imaging agents are also provided.
Claims19
A tumor imaging agent comprising a radionuclide associated with a targeting moiety by way of an auxiliary molecule, said targeting moiety comprising a residue of nucleotide polyphosphate precursor having formula A), B), C), or D):
- A) Nu1—(p)n—X
- B) Nu1—(p)n—X—(p)m—Nu2
- wherein, in the above formulas A)-D),
- (1) each of Nu1-Nu4 is adenosine;
- (2) p is a phosphate moiety;
- (3) X is an alkyl moiety or a choroalkyl moiety and X1, X2, and X3 are absent;
- and
- (4) (n+m) is from 2 to 8;
- and (r+q) is from 2 to 8.
A tumor imaging agent comprising a radionuclide associated with a targeting moiety by way of an auxiliary molecule, said targeting moiety comprising a residue of nucleotide polyphosphate precursor having formula A), B), C), or D):
- A) Nu1—(p)n—X
- B) Nu1—(p)n—X—(p)m—Nu2
- wherein, in the above formulas A)-D),
- (1) each of Nu1-Nu4 is an independently selected nucleoside;
- (2) p is a phosphate moiety;
- (3) X is an alkyl moiety or a choroalkyl moiety and X1, X2, and X3 are absent;
- and
- (4) (n+m) is from 2 to 8;
- and (r+q) is from 2 to 8.
A tumor imaging agent comprising a complex of 99mTc having the formula:
- where Ad is adenosine, and p is PO2H, and X is a 99mTc-containing chelating moiety.
A kit for tumor imaging which comprises a supply of a targeting precursor, said targeting precursor having formula A), B), C), or D):
- A) Nu1—(p)n—X
- B) Nu1—(p)n—X—(p)m—Nu2
- wherein, in the above formulas A)-D),
- (1) each of Nu1-Nu4 is adennine;
- (2) p is phosphate moiety;
- (3) X is an alkyl moiety or a choroalkyl moiety and X1, X2, and X3 are absent;
- and
- (4) (n+m) is from 2 to 8;
- and (r+q) is from 2 to 8.
A kit for tumor imaging which comprises a supply of a targeting precursor, said targeting precursor having formula A), B), C), or D):
- A) Nu1—(p)n—X
- B) Nu1—(p)n—X1—(p)m—Nu2
- wherein, in the above formulas A)-D),
- (1) each of Nu1-Nu4 is adennine;
- (2) p is phosphate moiety;
- (3) X is an alkyl moiety or a choroalkyl moiety and X1, X2, and X3 are absent;
- and
- (4) (n+m) is from 2 to 8;
- and (r+q) is from 2 to 8.
Dependencies are inferred from the claim text.