Small bore biologic graft with therapeutic delivery system
AssigneeSulzer Carbomedics Inc.
InventorsSteven G. Sullivan, Donald E. Chickering, John P. Ranieri
Life of this patent
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Abstract
A composite graft for a fluid-carrying vessel in a living body, comprising: an inner vessel comprising a biologic collagenic material that has been stabilized, an outer member surrounding at least a segment of the inner vessel and defining an annulus between the inner vessel and the sleeve, the outer member comprising a polymeric fabric, and a bioactive compound in said annulus, said bioactive compound being carried on a time-release vehicle. The bioactive compound is preferably an occlusion-preventing agent. Alternatively, the sleeve includes the bioactive compound, either on its inner surface or integrally as part of its fibers.
Claims32
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- an outer member surrounding at least a segment of said inner vessel and defining a space between said inner vessel and said outer member;
- and
- a bioactive compound in said space.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- an outer member surrounding at least a segment of said inner vessel and defining a space between said inner vessel and said outer member;
- and
- a bioactive compound in said space;
- wherein said bioactive compound comprises heparin.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- an outer member surrounding at least a segment of said inner vessel and defining a space between said inner vessel and said outer member;
- and
- a bioactive compound in said space;
- wherein said bioactive compound is carried on within resorbable polymeric microspheres.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- an outer member surrounding at least a segment of said inner vessel and defining a space between said inner vessel and said outer member;
- and
- a bioactive compound in said space;
- wherein said bioactive compound is carried in a resorbable synthetic coating on an inner surface of said outer member.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- an outer member surrounding at least a segment of said inner vessel and defining a space between said inner vessel and said outer member;
- and
- a bioactive compound in said space:
- wherein said bioactive compound is carried in particles of PLGA.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic material;
- and
- an outer sleeve member surrounding at least a segment of said inner vessel, said outer sleeve member comprising a resorbable material including an occlusion-preventing agent.
A method for implanting a graft vascular prosthesis on a host organ, comprising the steps of:
- providing a first tubular component having first and second ends;
- connecting the first end of the first tubular component at a first bypass point on the host organ;
- providing a second tubular component having first and second ends and sliding it over the first tubular component so as to define an annulus between the first and second tubular components;
- connecting the second end of the first tubular component at a second bypass point on the host organ;
- connecting the first and second ends of the second tubular component to the host organ;
- and
- including an occlusion-preventing agent in the annulus.
A composite graft for a fluid-carrying vessel in a living body, comprising:
- an inner vessel comprising a biologic collagenous material that has been stabilized;
- and
- an outer member surrounding at least a segment of said inner vessel and defining an annulus between said inner vessel and said outer member, said outer member comprising a polymeric fabric, and containing an occlusion-preventing agent carried in a time-release vehicle.
Dependencies are inferred from the claim text.