Transgenic mouse expressing APP770-V717F
AssigneeAdvanced Research and Technology Institute, Inc.
InventorsMerrill D. Benson, Jill Murrell, Martin Farlow, Bernardino Ghetti
Life of this patent
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Abstract
Methods for screening for risk of Alzheimer's disease involve assaying for a guanine to thymine substitution at position 1924 of the gene encoding the human amyloid precursor protein. Also described are transgenic non-human mammals, especially transgenic mice, harboring an expressable gene sequence encoding human amyloid precursor protein having a phenyalanine for valine amino acid substitution in the transmembrane domain of the amyloid precursor protein.
Claims2
A transgenic mouse whose genome comprises a DNA sequence encoding a human amyloid precursor protein which contains a valine to phenylalanine substitution at amino acid position 717 operably linked to a promoter, and wherein expression of the DNA sequence results in detectable levels of the amyloid protein in the brain of the mouse.
Dependencies are inferred from the claim text.