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US 6,184,422 B2Granted
Cyclohexanediol derivatives
AssigneeHoffman-La Roche Inc.
InventorsPierre Barbier, Franz Bauer, Peter Mohr, Marc Muller, Wolfgang Pirson
Life of this patent
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Abstract
Compounds of formula I wherein X is C═CH2 or CH2; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is —C≡C—, —CH═CH— or —CH2—CH2—, R1 and R2 are independently of each other alkyl or perfluoroalkyl; and R3 is lower alkyl are useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated with photodamage.
Claims27
A compound of the formula:
- wherein
- X is C═CH2 or CH2;
- Y and Z are independently of each other hydrogen, fluorine or hydroxy;
- A is —C≡C—, —CH═CH— or —CH2—CH2—;
- R1 and R2 are independently of each other alkyl or perfluoroalkyl;
- and
- R3 is lower alkyl.
4 more elements
A compound of the formula:
- wherein
- X is C═CH2 or CH2;
- A is —C≡C—, —CH═CH— or —CH2—CH2—;
- R1 and R2 are independently of each other alkyl or perfluoroalkyl;
- R3 is lower alkyl;
- Y′ and Z′ are tert-butyidimethylsilyloxy or trimethylsilyloxy;
- and
- R4 is trimethylsilyl.
5 more elements
Dependencies are inferred from the claim text.