Method for preparing acetophenones with a fluoralkyl-substituted aromatic nucleus
AssigneeBayer Aktiengesellschaft
InventorsWulf Kühnle, Albrecht Marhold, Guido Steffan
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Abstract
Acetophenones which are substituted on the aromatic ring by fluoroalkyl are prepared in a particularly advantageous, environmentally friendly and effective manner from fluoroalkylanilines and acetaldoxime by preparing from a fluoroalkylaniline a corresponding diazonium salt solution, and reacting this with acetaldoxime in the presence of at least one copper compound, without adding any buffer salts or reducing agents, carrying out the reaction at from 20 to 50° C. and in the presence of halide ions and subsequently heating to a temperature in the range from 70 to 110° C.
Claims9
Process for preparing acetophenones which are substituted on the aromatic ring by fluoroalkyl from fluoroalkylanilines and acetaldoxime, in which from a fluoroalkylaniline a corresponding diazonium salt solution is prepared the process comprising reacting the diazonium salt solution with acetaldoxime in the presence of at least one copper compound, wherein no buffer salts and no reducing agents are added, wherein the reaction is carried out at from 20 to 50° C. and in the presence of halide ions and the mixture is subsequently heated to a temperature in the range from 70 to 110° C.
Dependencies are inferred from the claim text.