Supported phase catalyst
AssigneeCalifornia Institute of Technology
InventorsMark E. Davis, Kam To Wan
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Abstract
Supported phase catalysts in which the support phase is highly polar, most preferably ethylene glycol or glycerol, are disclosed. An organometallic compound, preferably a metal complex of chiral sulfonated 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl is dissolved in the support phase. Such supported phase catalysts are useful for asymmetric synthesis of optically active compounds, including the asymmetric hydrogenation of prochiral unsaturated carbon-hetero atom bonds, such as ketones, imines and beta-keto esters.
Claims10
A method for conducting an asymmetric reaction to a prochiral unsaturated bond contained within a compound comprising the step of contacting said compound with a supported liquid phase catalyst comprising an organometallic compound which comprises a metal and a chiral sulfonated 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl solubilized in a solvent having at least two alcohol groups,
- wherein each phenyl group of the 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl is at least monosulfonated, and
- wherein the degree to which the 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl is sulfonated is selected from the group consisting of tetrasulfonated, pentasulfonated, and hexasulfonated.
Dependencies are inferred from the claim text.