Process for the selective alkylation of aldehydes by means of organozinc compounds

A process for the enantioselective alkylation of aldehydes with organozinc compounds, comprising transferring a functionalized alkyl group (R-FG) to an aldehyde according to the equation I

• wherein R1 is selected from the group consisting of alkyl, aryl, functionalized alkyl and functionalized aryl,
• RDum is an organic residue selected from the group consisting of
• —CH2—C(R2, R3, R4) wherein
• R2 is selected from the group consisting of H, alkyl and aryl;
• R3 is selected from the group consisting of alkyl and aryl;
• R4 is selected from the group consisting of alkyl and aryl,
• and —CH—(CH3)(R5) wherein
• R5 is alkyl;
• (R-FG) is selected from the group consisting of alkyl and a functionalized alkyl group having a ketocarbonyl, ester, amine, carboxylic acid amide, nitrile, cyanate, isocyanate, ether, enolether, halogen, aromatic or CC multiple-bond function, wherein
• RDum≠R-FG;
• and wherein the solvent is selected from the group consisting of a 5 to 12 carbon aliphatic hydrocarbon, an aromatic hydrocarbon, an ether and a chlorinated hydrocarbon, and
• wherein * in compound IV is a chiral center of compound IV.