Combinatorial libraries having aminodiol monomer subunits
AssigneeIsis Pharmaceuticals, Inc.
InventorNormand Hebert
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Abstract
Combinatorial libraries are constructed to include aminodiol monomer subunits connected by phosphodiester, phosphorothioate, or phosphoramidate linking moieties. Combinatorial libraries of the invention feature a plurality of functional groups attached to backbone and phosphoramidate combinatorial sites.
Claims12
An oligomeric compound consisting essentially of at least two aminodiol monomer subunits joined by liing groups, wherein each of said aninodiol monomer subnuits has the structure I, II, or III:
- wherein:
- n is 0 to 5;
- R1 is —T—L;
- T is a group of formula —R—C(═O)— where R is alkyl;
- L is 2-thienyl or 3-thienyl;
- R2 is H or an alkyl group having from 1 to 10 carbons;
- R3 and R4 are each independently H, or R3 and R4 together from an isoposhoraidate linking group.
A library of oligomers, ecah of said oligomers consisting essentially of at least two aminodiol monomer subunits joined by linking groups, said aminodiol monomer subunits having the structure I, II or III:
- wherein:
- n is 0 to 5;
- R1 is —T—L;
- T is a group of formula —R—C(═O)— where R is alkyl;
- L is 2-thienyl or 3-thienyl;
- R is H or an alkyl group having from 1 to 10 carbons;
- R3 and R4 are each independently H, or R3 and R4 together form an isophoshoramidate linking group.
Dependencies are inferred from the claim text.