Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives

A compound represented by the formula:

• wherein
• R111 represents a protective group for an amino group;
• R2 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, provided that the alkyl group may have one or more substituents selected from the group consisting of a halogen atom, a hydroxyl group, and an alkoxy group having 1 to 6 carbon atoms;
• R3 and R5 each represent a hydrogen atom and which form a cis-configuration;
• R4 represents a hydroxyl group, a halogen atom, a carbamoyl group, an alkyl group having 1 to 6 carbon atoms, an alkoxyl group having 1 to 6 carbon atoms or an alkylthio group having 1 to 6 carbon atoms, provided that the alkyl group may have one or more substituents selected from the group consisting of a hydroxyl group, a halogen atom and an alkoxy group having 1 to 6 carbon atoms, and
• where R4 and the substituent on the pyrrolidine ring of the following formula:
• form a cis-configuration;
• R6 and R7 each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;
• n is an integer of from 1 to 3;
• Q′ represents an amino-protective group selected from the group consisting of an optionally substituted alkoxycarbonyl group, an optionally substituted aralkyloxycarbonyl group, an optionally substituted acyl group, an optionally substituted alkyl group, an optionally substituted aralkyl group and a substituted silyl group;
• and
• when R111 and Q′ are both protective groups for the amino group, each may be the same or different from the other, and may include an optionally substituted alkoxycarbonyl group.