Lactoferrin receptor genes of Moraxella
AssigneeConnaught Laboratories Limited
InventorsSheena M. Loosmore, Run-Pan Du, Quijun Wang, Yan-Ping Yang, Michel H. Klein
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Abstract
Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as M. catarrhalis, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 and ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
Claims5
A purified and isolated nucleic acid molecule having a DNA sequence selected from the group consisting of:
- (a) a DNA sequence having SEQ ID No. 69 or the fully complementary DNA sequence thereto;
- (b) a DNA sequence encoding an amino acid sequence having SEQ ID No. 70 or the fully complementary DNA sequence thereto;
- and
- (c) a DNA sequence encoding a functional lactoferrin receptor protein of Moraxella and which hybridizes under high stringency conditions to any one of the sequences defined in (a) or (b).
A transformed host containing an expression vector as claimed in claimed 4.
Dependencies are inferred from the claim text.