Substituted liposaccharides useful in the treatment and prevention of endotoxemia

A compound having the formula:

• wherein R2 is a straight chained or branched C5 to C15 alkyl group;
• and R1 is selected from the group consisting of:
• wherein each J, K and Q, independently, is straight or branched C1 to C15 alkyl;
• L is O, NH or CH2;
• M is O or NH;
• and G is NH, O, S, SO or SO2.

A compound having the formula:

• wherein R4 is selected from the group consisting of straight or branched C4 to C15 alkyl, and
• where each U and V, independently, is straight or branched C2 to C15 alkyl and W is hydrogen or straight or branched C1 to C5 alkyl;
• and
• RA is R5 or R5—O—CH2—, where R5 is selected from the group consisting of hydrogen, —J′, —J′—OH, —J′—O—K′, —J′—O—K′—OH, and —J′—O—PO(OH)2, where each J′ and K′, independently, is straight or branched C1 to C15 alkyl.

A compound having the formula:

• wherein R4 is selected from the group consisting of straight or branched C4 to C15 alkyl, and
• where each U and V, independently, is straight or branched C2 to C15 alkyl and W is hydrogen or straight or branched C1 to C5 alkyl;
• and
• RA is R5 or R5—O—CH2—, where R5 is selected from the group consisting of hydrogen, —J′, —J′—OH, —J′—O—K′, —J′—K′—OH, and —J′—O—PO(OH)2, where each J′ and K′, independently, is straight or branched C1 to C15 alkyl.