Antibodies to epithelium-derived T-cell factor
AssigneeImmunex Corporation
InventorsKenneth H. Grabstein, Dirk M. Anderson, June R. Eisenman, Victor Fung, Charles Rauch
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Abstract
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating or preventing gastrointestinal diseases and HIV or HIV-associated diseases.
Claims22
A humanized antibody which specifically binds epithelium-derived T-cell factor polypeptide, wherein said polypeptide is selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3;
- (b) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 6;
- and
- (c) a polypeptide encoded by an isolated nucleic acid selected from the group consisting of:
- (i) DNA comprising nucleotides 145 through 486 of the DNA sequence of SEQ ID NO:
- 1 or 4;
- (ii) DNA that detectably hybridizes to the DNA of (i) or their complementary strands under conditions of high stringency and upon expression encodes epithelium-derived T-cell factor;
- and
- (iii) DNA that, due to the degeneracy of the genetic code, encodes a polypeptide, encoded by any of the foregoing DNA sequences.
A transgenic antibody which specifically binds epithelium-derived T-cell factor polypeptide, wherein said polypeptide is selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 3;
- (b) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 6;
- and
- (c) a polypeptide encoded by an isolated nucleic acid selected from the group consisting of:
- (i) DNA comprising nucleotides 145 through 486 of the DNA sequence of SEQ ID NO:
- 1 or 4;
- (ii) DNA that detectably hybridizes to the DNA of (i) or their complementary strands under conditions of high stringency and upon expression encodes epithelium-derived T-cell factor;
- and
- (iii) DNA, that due to the degeneracy of the genetic code, encodes a polypeptide encoded by any of the foregoing DNA sequences.
An isolated antibody which specifically binds epithelium-derived T-cell factor polypeptide wherein said polypeptide consists of the amino acid sequence SEQ ID NO:
- 6.
An isolated antibody which specifically binds epithelium derived T-cell factor polypeptide, wherein said polypeptide consists of the amino acid sequence SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.