Soluble extracellular domain of human M-CSF receptor
AssigneeChiron Corporation
InventorsKirston Koths, Eric Taylor
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Abstract
The present invention is directed to methods for crystallizing macrophage colony stimulating factor. The present invention is also directed to methods for designing and producing M-CSF agonists and antagonists using information derived from the crystallographic structure of M-CSF. The invention is also directed to methods for screening M-CSF agonists and antagonists. In addition, the present invention is directed to an isolated, purified, soluble and functional M-CSF receptor.
Claims3
An isolated, purified, and soluble extracellular domain fragment of a human macrophage colony stimulating factor (M-CSF) receptor comprising the amino acid sequence of SEQ ID NO:11 and wherein said extracellular domain fragment does not comprise a transmembrane region.
An isolated, purified, and soluble extracellular domain fragment of a human macrophage colony stimulating factor (M-CSF) receptor consisting essentially of the amino acid sequence of SEQ ID NO:11 and wherein said extracellular domain fragment does not comprise a transmembrane region.
An isolated, purified, and soluble and dimerizing extracellular domain fragment of a human macrophage colony stimulating factor (M-CSF) receptor, wherein said extracellular domain fragment consists of the amino acid sequence of SEQ ID NO:11.
Dependencies are inferred from the claim text.