Loading patent…
AssigneeSyntex (U.S.A.) Inc.
InventorsRonald Herman, Stephen Gregory Delgado, Linda Marie Fish, Lakshmi Sangameswaran, Douglas Kenneth Rabert
Estimating the term…
The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
Purified and isolated peripheral nerve tetrodotoxin-resistant sodium channel protein having the amino acid sequence set forth in FIG. 2 (SEQ ID NO:2).
Purified and isolated peripheral nerve tetrodotoxin-resistant sodium channel protein having the amino acid sequence set forth in FIG. 6 (SEQ ID NO:10).
Dependencies are inferred from the claim text.