Functional recombinantly prepared synthetic protein polymer
AssigneeProtein Polymer Technologies, Inc.
InventorsFranco A. Ferrari, Joseph Cappello
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Abstract
Novel polymers are provided which are produced by recombinant techniques. The polymers are characterized by having a small repeating sequence which provides for strands capable of associating, resulting in useful structural characteristics, where the strands are joined by turns or loops which are flexible and available for interaction with the environment. Specifically, repeating groups of naturally occurring proteins such as silk are modified by introduction of an amino-acid sequence at a site which provides for a turn between strands to provide for readily available oligopeptides capable of interacting with molecules in the environment.
Claims14
A recombinantly produced proteinaceous polymer composition comprising a proteinaceous polymer of at least about 15 kDal that comprises strands of repeating units of a natural protein capable of assembling into aligned structures to be formable into articles, wherein at least one of said strands comprises a tandem repeat of said repeating units, with at least two strands joined by an intervening oligopeptide other than said repeating units and wherein said composition is substantially homogeneous.
A recombinantly produced proteinaceous polymer composition comprising a proteinaceous polymer of at least about 15 kDal which comprises strands of repeating units having the sequence GAGAGS (SEQ ID NO:
- 119), VPGVG (SEQ ID NO:2), or at least one of GPP and GAP and capable of assembling into aligned structures to be formable into articles, wherein at least one of said strands comprises a tandem repeat of said repeating units, with at least two strands joined by an intervening oligopeptide other than said repeating units and wherein said composition is substantially homogeneous.
Dependencies are inferred from the claim text.