Fetal globin inducing factor
OwnerGeorge Stamatoyannopoulos, Thalia Papayannopoulouinventors
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Abstract
The invention is directed to fetal globin inducing factor (FGIF), and to nucleic acids encoding FGIF. FGIF controls the expression of fetal globin gene products. An FGIF polypeptide is shown in FIG. 3 and nucleotide sequences that encode FGIF polypeptides are shown in FIGS. 1 and 2. The invention is also directed to therapeutic methods employing FGIF polypeptides, encoding nucleic acids and functional fragments thereof for the treatment of globin disorders and to methods for screening compounds that modulate fetal globin gene expression as well as compounds identified by these methods.
Claims4
An isolated amino acid sequence or an active fragment of said sequence that functions to regulate expression of a globin gene wherein said sequence comprises SEQ ID NO:3 or SEQ ID NO:3 with one or more conservative amino acid substitutions.
Dependencies are inferred from the claim text.