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US 6,184,245 B2Granted
Cyclic ketone derivatives and their medical applications
AssigneeToray Industries, Inc.
InventorsYuji Sugawara, Hideki Kawai, Tsuyoshi Matsumoto, Kiyoshi Okano, Satoko Takizawa
Life of this patent
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Abstract
The present invention relates to cyclic ketones represented by the following formula and to drugs in which an effective component is such a cyclic ketone or a pharmacologically acceptable salt thereof. The cyclic ketones of the present invention encourage the production of blood platelets, leukocytes and erythrocytes, and can be employed in the prevention or treatment of cytopaenia brought about by cancer chemotherapy, radiotherapy or drug therapy, or by immunological abnormality, anaemia and the like.
Claims9
A cyclic ketone compound represented by formula (I):
- where R1, R2 and R3 are independently a hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1 to C10 alkyl group, C1 to C10 alkenyl group, C1 to C10 alkynyl group, C6 to C12 aryl group, C6 to C12 arylalkyl group, C6 to C12 alkylaryl group, C6 to C12 arylalkenyl group, or —(CH2)pZ (where p represents an integer in the range 0 to 3, and Z represents a cyano group, carboxyl group, methylthio group, phenylthio group, trifluoromethyl group or methylthiomethyl group, with the proviso that R1, R2 and R3 are not all substituents selected from the hydrogen atom, fluorine atom, chlorine atom and bromine atom,
- R4 and R5 respectively independently represent a hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1 to C6 alkyl group, hydroxy group, C1 to C6 alkoxy group, carboxy group or C2 to C10 alkoxycarbonyl group,
- R6 represents a hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1 to C10 alkyl group, C6 to C12 aryl group, C6 to C12 arylalkyl group, C6 to C12 alkylaryl group, C6 to C12 arylalkenyl group, or —(CH2)qG (where q represents an integer in the range 1 to 3, and G represents a hydroxyl group or C2 to C10 alkoxycarbonyl group),
- R7 represents a hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1 to C10 alkyl group, C6 to C12 aryl group, carboxy group or C2 to C10 alkoxycarbonyl group,
- R8 represents a hydrogen atom or C1 to C10 alkyl group,
- X is O or S, and
- Y is O or S, or pharmacologically acceptable salts thereof.
4 more elements
Dependencies are inferred from the claim text.