N-linked ureas and carbamates of heterocyclic thioesters

A compound of formula I:

• or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein:
• A and B are taken together, with the nitrogen and carbon atoms to which they are respectively attached, to form a pyrazoline ring;
• X is either O or S;
• Y is a direct bond to Z, or a C1-C6 straight or branched chain alkyl or alkenyl, wherein any of the carbon atoms of said alkyl or alkenyl are optionally substituted in one or more positions with oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl is optionally replaced with O, NH, NR2, S, SO, or SO2, where R2 is selected from the group consisting of hydrogen, (C1-C4)-straight or branched chain alkyl, (C3-C4)-straight or branched chain alkenyl or alkynyl, and (C1-C4) bridging alkyl wherein a bridge is formed between the nitrogen and a carbon atom of said alkyl or alkenyl chain containing said heteroatom to form a ring, wherein said ring is optionally fused to an Ar group;
• Z is a direct bond, or a C1-C6 straight or branched chain alkyl or alkenyl, wherein any of the carbon atoms of said alkyl or alkenyl is optionally substituted in one or more positions with oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl is optionally replaced with O, NH, NR2, S, SO, or SO2, where R2 is selected from the group consisting of hydrogen, (C1-C4)-straight or branched chain alkyl, (C3-C4)-straight or branched chain alkenyl or alkynyl, and (C1-C4) bridging alkyl wherein a bridge is formed between the nitrogen and a carbon atom of said alkyl or alkenyl chain containing said heteroatom to form a ring, wherein said ring is optionally fused to an Ar group;
• C and D are independently:
• hydrogen, or Ar, or C1-C6 straight or branched chain alkyl or alkenyl which is optionally substituted in one or more position(s) with C3-C8 cycloalkyl, C5-C7 cycloalkenyl, hydroxyl, carbonyl oxygen, or with Ar, wherein said alkyl, alkenyl, cycloalkyl or cycloalkenyl groups is optionally substituted with C1-C4 alkyl, C1-C4 alkenyl, or hydroxy, wherein any of the carbon atoms of said alkyl or alkenyl is optionally substituted in one or more positions with oxygen to form a carbonyl, or wherein any of the carbon atoms of said alkyl or alkenyl is optionally replaced with O, NH, NR2, S, SO, or SO2, where R2 is selected from the group consisting of hydrogen, (C1-C4)-straight or branched chain alkyl, (C3-C4)-straight or branched chain alkenyl or alkynyl, and (C1-C4) bridging alkyl wherein a bridge is formed between the nitrogen and a carbon atom of said alkyl or alkenyl chain containing said heteroatom to form a ring, wherein said ring is optionally fused to an Ar group;
• wherein Ar is a mono-, bi-, or tricyclic, carbo- or heterocyclic ring, wherein the ring is either unsubstituted or substituted in one to three position(s) with halo, hydroxyl, nitro, trifluoromethyl, C1-C6 straight or branched chain alkyl or alkenyl, C1-C4 alkoxy, C1-C4 alkenyloxy, phenoxy, benzyloxy, amino, or a combination thereof;
• wherein the individual ring sizes are 5-6 members;
• wherein the heterocyclic ring contains 1-6 heteroatom(s) selected from the group consisting of O, N, S, or a combination thereof;
• wherein aromatic or tertiary alkyl amines are optionally oxidized to a corresponding N-oxide;
• W is oxygen or sulfur;
• U is either O or N, wherein when U is O, then R1 is a lone pair of electrons and R2 is selected from the group consisting of:
• Ar as defined above, or
• C3-C8 cycloalkyl, or
• C1-C6 straight or branched chain alkyl or alkenyl substituted in one or more positions with Ar as defined above, or with C3-C8 cycloalkyl;
• and when U is N,
• R1 and R2 are selected independently from the group consisting of
• Hydrogen, or
• Ar as defined above, or
• C3-C8 cycloalkyl, or
• C1-C6 straight or branched chain alkyl or alkenyl, or
• C1-C6 straight or branched chain alkyl or alkenyl substituted in one or more positions with Ar as defined above, or with C3-C8 cycloalkyl;
• or R1 and R2 may be taken together to form a pyrazoline ring.