Pharmacologic drug combination in vagal-induced asystole
AssigneeEmory University
InventorJohn D. Puskas
Life of this patent
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Abstract
Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of the vagus nerve and administration of a combination of drugs.
Claims14
A pharmaceutical composition, comprising an acetylcholinesterase inhibitor, a β-adrenergic receptor blocker, and a calcium channel blocker.
A pharmaceutical composition, comprising an acetylcholinesterase inhibitor, wherein the acetylcholinesterase inhibitor is pyridostigmine bromide, a β-adrenergic receptor blocker, wherein the βadrenergic receptor blocker is propranolol hydrochloride, and a calcium channel blocker, wherein the calcium channel blocker is verapamil bromide.
A pharmaceutical composition, comprising acetylcholinesterase inhibitor pyridostigmine bromide at a concentration in the range of about 0.1 mg/kg to about 2.0 mg/kg, β-adrenergic receptor blocker propanolol hydrochloride at a concentration in the range of about 0.01 mg/kg to about 2.0 mg/kg, and calcium channel blocker verapamil bromide at a concentration in the range of about 0.01 mg/kg to about 0.2 mg/kg.
Dependencies are inferred from the claim text.