Substituted pyridine compounds and methods of use

A compound of the formula

• or a pharmaceutically acceptable salt thereof, wherein
• X is O, S, S(O), S(O)2 or NR2;
• Y is —C(O)—NR3R4 or —NR4—C(O)—R3;
• R1 is a pyridyl radical which is optionally substituted by 1-4 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R18—Z18— or R18—Z18-alkyl;
• provided that the total number of aryl and heteroaryl radicals in R1 is 1-3;
• R2 is a hydrogen or alkyl radical;
• R3 is an aryl or heteroaryl radical which is optionally substituted by 1-5 radicals of alkyl, halo, haloalkyl, cyano, azido, nitro, amidino, R19—Z19— or R19—Z19-alkyl;
• provided that the total number of aryl and heteroaryl radicals in R3 is 1-3;
• and provided when Y is —C(O)—NR3R4, R3 is other than a phenyl or naphthyl having an amino, nitro, cyano, carboxy or alkoxycarbonyl substituent bonded to the ring carbon atom adjacent to the ring carbon atom bonded to —NR4—;
• and
• R4 is a hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or R20—Z20-alkyl radical;
• wherein R18, R19 and R20 are each independently a hydrogen, alkyl, haloalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl radical;
• wherein the aryl and heteroaryl radicals of R4, R18, R19 and R20 are optionally substituted by 1-3 radicals of hydroxy, alkoxy, alkylthiol, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylamino, alkoxycarbonyl, cyano, halo, azido, alkyl, haloalkyl or haloalkoxy;
• and
• Z18, Z19 and Z20 are each independently —O—, —S—, —S(O)—, —S(O)2—, —CO2—, —C(O)—, —NR21—, —NR21—C(O)—, —C(O)—NR21—, —NR21—S(O)2— or —S(O)2—NR21—;
• wherein each R21 is independently a hydrogen or alkyl radical;
• R5 and R6 are each independently a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, amino, alkylamino, dialkylamino, alkanoylamino, alkylsulfonylamino, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl radical;
• and
• R7 is a hydrogen, alkyl, halo, haloalkyl, haloalkoxy, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl, hydroxy, hydroxyalkyl, thiol, alkylthiol, alkylsulfinyl, alkylsulfonyl, alkoxy, alkoxyalkyl, cyano, azido, nitro, carboxy, alkoxycarbonyl, aminocarbonyl alkylaminocarbonyl or dialkylaminocarbonyl radical;
• wherein aryl is a phenyl or biphenyl radical which is optionally benzo fused or heterocyclo fused;
• and heteroaryl is a monocyclic or bicyclic aromatic heterocyclic ring system having 5-6 ring members per ring, wherein 1-3 ring members are oxygen, sulfur or nitrogen heteroatoms, which is optionally saturated C3-C4-carbocyclic-fused;
• and
• provided when X is O or S and R4 is a hydrogen radical, then R3 is other than a tert-butylphenyl radical;
• and when Y is —NR4—C(O)—R3, then R3 is other than an optionally substituted 1-indolinyl radical.