Back to results
US 6,184,231 B2Granted
3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators
AssigneeBristol-Myers Squibb Company
InventorsPiyasena Hewawasam, John E. Starrett, Jr.
Life of this patent
Estimating the term…
Abstract
The present invention provides novel 3-substituted-4-arylquinolin-2-one derivatives having the general formula wherein R, R1, R2, R3, R4, R5, R6 and R7 are as defined herein, or a non-toxic pharmaceutically acceptable salt thereof which are modulators of the large conductance calcium-activated K+ channels and are useful in the treatment of disorders which are responsive to the opening of the potassium channels.
Claims14
A compound of the formula
- wherein
- R and R1 each are independently hydrogen or methyl;
- R2, R3 and R4 each are independently hydrogen, halogen, nitro or trifluoromethyl, provided R2, R3, and R4 are not all hydrogen;
- R5 is bromo, chloro or nitro;
- R6 is hydrogen or fluoro;
- n is an integer from 0 to 6;
- m is an integer of 0 or 1;
- and
- R7 is CH3, —CRR1OH, —CHO, —C═NOH, —COCH3 or aryl optionally substituted by one or two substituents selected from the group consisting of halogen, hydroxy, methoxy, amino, acetylamino and trifluoromethyl;
- or a nontoxic pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.