Quinazoline derivatives as inhibitors of P-38 α

A method to specifically inhibit p-38 α-kinase which method comprises contacting p-38 α-kinase with a compound of the formula:

• or the pharmaceutically acceptable salts thereof
• wherein each R2 is independently selected from the group consisting of R4, halo, OR4, NR42, SR4, —OOCR4, —NR4OCR4, —COOR4, R4CO, —CONR42, —SO2NR42, CN, CF3, and NO2, wherein each R4 is independently H, or optionally substituted alkyl (1-6C), or optionally substituted arylalkyl (7-12C) and wherein two R2 taken together may form a fused ring of 5-7 members;
• m is an integer of 0-4;
• R1 is H, alkyl (1-6C) or arylalkyl optionally substituted on the aryl group with 1-3 substituents independently selected from alkyl (1-6C), halo, OR, NR2, SR, —OOCR, —NROCR, RCO, —COOR, —CONR2, —SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C);
• n is 0, 1 or 2;
• Ar is phenyl, pyridyl, indolyl, or pyrimidyl, each optionally substituted with a group selected from the group consisting of optionally substituted alkyl (1-6C), halo, OR, NR2, SR, —OOCR, —NROCR, RCO, —COOR, —CONR2, SO2NR2, CN, CF3, and NO2, wherein each R is independently H or lower alkyl (1-4C);
• and
• R3 is a branched (5-7C) or cyclic alkyl group (5C or 7C) or is phenyl optionally substituted with 1-2 substituents which substituents are selected from the group consisting of alkyl (1-6C), halo, SR, —OOCR, —NROCR, RCO, —COOR, —CONR2, —SO2NR2, CN, and CF3, wherein each R is independently H or lower alkyl (1-4C).