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US 6,184,220 B2Granted
Oral suspension of pharmaceutical substance
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsDietrich Türck, Veit Schmelmer
Life of this patent
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Abstract
The present invention relates to orally administered suspensions of pharmaceutical active substances of the NSAID type, particularly the antirheumatic agent Meloxicam, which are stabilized by the addition of small amounts of highly dispersed silicon dioxide using high shear forces and adding small amounts of hydrophilic polymers to form a three-dimensional siloid structure, and a process for the preparation thereof.
Claims13
A pharmaceutical composition of matter which is an orally administered suspension comprising
- particles of a non-steroidal anti-inflammtory active substance selected from the acid enolcarboxamides (oxicams), and pharmaceutically acceptable salts thereof, having a suspendable particle size spectrum in which at least 90% of the particles are smaller than 50 μm,
- a physiologically inert dispersion medium in which the particles of active substance are suspended and in which dispersion medium the active substance has a solubility of less than 500 μg/ml, about 0.1 to about 5% by weight of highly dispersed silicon dioxide having a specific surface area of at least 50 m2/g, forming a three-dimensional siloid structure produced by adding the silicon dioxide to the dispersion medium with the action of shear forces characterised by a circumferential rotor speed of about 15 to 35 m/s, and
- about 0.05 to about 2% by weight of a hydrophilic polymer, which polymer is soluble in the dispersion medium.
Dependencies are inferred from the claim text.