Treatment of skin conditions with oxysterol activators of LXRα
AssigneeThe Regents of the University of California
InventorsPeter M. Elias, Nathan N. Bass, Karen Hanley, Kenneth R. Feingold
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Abstract
Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor α, and oxysterol activators of the LXRα receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.
Claims7
A method for treating the epidermis of a terrestrial mammalian subject suffering from a perturbed epidermal barrier function, said method comprising topically administering to said epidermis a topical composition comprising an active ingredient that is an oxysterol activator of
- LXRα selected from the group consisting of 22(R)-hydroxycholesterol,
- 25-hydroxycholesterol, 7a-hydroxycholesterol, 24-hydroxycholesterol,
- 27-hydroxycholesterol, 40-hydroxycholesterol, 20,22-dihydroxycholesterol, and
- 20(S)-hydroxycholesterol, said active ingredient being present in a concentration that is effective in enhancing barrier development.
A method for treating the epidermis or mucous membrane of a terrestrial mammalian subject suffering from a condition of disturbed differentiation or excess proliferation, said method comprising topically administering to said epidermis or mucous membrane a topical composition comprising an active ingredient that is an oxysterol activator of LXRα selected from the group consisting of
- 22(R)-hydroxycholesterol, 25-hydroxycholesterol, 7a-hydroxycholesterol,
- 24-hydroxycholesterol, 27-hydroxycholesterol, 4β-hydroxycholesterol,
- 20,22-dihydroxycholesterol, and 20(S)-hydroxycholesterol, said active ingredient being present in a concentration that is effective in normalizing said condition.
Dependencies are inferred from the claim text.