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US 6,184,210 B2Granted
Dipeptide apoptosis inhibitors and the use thereof
AssigneeCytovia, Inc.
InventorsJohn F. W. Keana, Sui Xiong Cai, John Guastella, Wu Yang, John A. Drewe
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Abstract
The present invention is directed to novel dipeptides thereof, represented by the general Formula I: where R1-R3 and AA are defined herein. The present invention relates to the discovery that compounds having Formula I are potent inhibitors of apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
Claims15
A compound of formula II:
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is an N-terminal protecting group selected from the group consisting of t-butoxycarbonyl (Boc), acetyl (Ac) and benzyloxycarbonyl (Cbz);
- R3 is alkyl or hydrogen;
- and
- AA is a residue of an amino acid selected from the group consisting of valine (Val), isoleucine (Ile) and leucine (Leu).
2 more elements
Dependencies are inferred from the claim text.