Diabetes treatment
AssigneeAlizyme Therapeutics Limited
InventorMargaret Elizabeth Smith
Life of this patent
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Abstract
Diabetes Mellitus type I or II is treated by use of a peptide including an amino acid sequence comprising part of a 10 amino acid C-terminal fragment of β-endorphin.
Claims19
A method of treating a patient with diabetes mellitus, comprising the step of administering to such patient an effective amount of a peptide containing a 2-10 amino acid peptide analogue of β-endorphin 22-31 which comprises a dipeptide X-Y representing amino acids 30-31 of β-endorphin as its C-terminus and one or more N-terminal amino acids which are the same or different from amino acids 22-29 of β-endorphin;
- wherein X is Gly, Sar, AzGly, Ala, D-Ala, D-Ser or Pro;
- and wherein Y is Glu or Gln.
A method of increasing uptake of blood glucose into muscle in a patient, comprising the step of administering to such patient an effective amount of a 2-10 amino acid peptide analogue of β-endorphin 22-31 which comprises a dipeptide X-Y representing amino acids 30-31 of β-endorphin as its C-terminus and one or more N-terminal amino acids which are the same or different from amino acids 22-29 of β-endorphin;
- wherein X is Gly, Sar, AzGly, Ala, D-Ala, D-Ser or Pro;
- and wherein Y is Glu or Gln.
A method of treating a patient with diabetes mellitus, comprising the step of administering to such patient an effective amount of a 2-10 amino acid peptide analogue of β-endorphin 22-31 which comprises a dipeptide X-Glu representing amino acids 30-31 of β-endorphin as its C-terminus;
- wherein X is an amino acid residue selected from the group consisting of Gly, Sar, AzGly, Ala, D-Ala, D-Ser and Pro.
A method of treating a patient with diabetes mellitus, comprising the step of administering to such patient an effective amount of a 2-10 amino acid peptide analogue of β-endorphin 22-31 which comprises a tetra-peptide Ac-Lys-D-Lys-Sar-Glu representing amino acids 28-31 of β-endorphin as its C-terminus.
Dependencies are inferred from the claim text.