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US 6,184,203 B2Granted
Regulation of oxidative burst using LMWG-derived peptides and analogs
AssigneeThe Scripps Research Institute
InventorsGary M. Bokoch, John T. Curnutte
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AssigneeThe Scripps Research Institute
InventorsGary M. Bokoch, John T. Curnutte
Estimating the term…
The present invention relates to optionally substituted, non-toxic peptides and derivatives capable of inhibiting superoxide production in phagocytic cells. The invention also relates to compositions and methods useful in inhibiting inflammation and in treating inflammatory disorders such as autoimmune disorders, gout, adult respiratory distress syndrome, asthma, myocardial infarction, and various dermatological disorders. The present invention contemplates compositions derived from low molecular weight GTP-binding proteins (LMWG), mastoparan, GAP proteins, and related peptides. The invention further contemplates compositions useful in inhibiting activation of NADPH oxidase or in promoting GDP/GTP exchange. Therapeutic compositions containing various inhibitors, and methods of using same, are also disclosed.
A process of inhibiting inflammation in an individual in need of such treatment comprising administering to the individual an effective amount of a peptide NADPH oxidase inhibitor, wherein the inhibitor inhibits ADPH oxidase activity in a cell-free assay containing (i) neutrophil cell cytosol, (ii) deoxycholate-treated neutrophil cell membranes and (iii) a Rac protein.
Dependencies are inferred from the claim text.