US 6,184,202 B2Granted

Cell death regulators

AssigneeWashington University

InventorStanley J. Korsmeyer

Life of this patent

Estimating the term…

Abstract

The invention provides a bcl-2 related protein, bcl-2 muteins, two-hybrid systems comprising interacting bcl-2-related polypeptide sequences, and uses thereof.

Claims10

Dependent claims

A method for modulating apoptosis of a cell which comprises administering to the cell an agent which comprises a BH1domain or a BH2 domain and is capable of promoting or inhibiting formation of at least one complex selected from the group consisting of bcl-2:bcl-2 complexes, bcl-XL:bcl-XL complexes, Bax:Bax complexes, bcl-2:Bax complexes, and bcl-XL:Bax complexes.

Dependencies are inferred from the claim text.

Facts

Application: 08/927,326Filed 11 Sep 1997 · division
Priority: 26 Aug 1993
Granted: 6 Feb 2001
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 14/82
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: translation products from oncogenes
A61P 35/00
Antineoplastic agents
C07K 14/4747
Not used: apoptosis related proteins
A01K 2217/05
Genetically modified animals: animals comprising random inserted nucleic acids

Family

Application08/112,208Parent of this continuation-in-part · filed 26 Aug 1993
Application08/248,819Parent of this continuation-in-part · filed 25 May 1994
Application08/337,646Parent of this division · filed 10 Nov 1994
US 5,856,171 AParent of this division
Application08/337,646Parent of this continuation-in-part
US 5,700,638 AParent of this continuation-in-part
US 5,691,179 AParent of this continuation-in-part
US 6,184,202 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

The invention provides a bcl-2 related protein, bcl-2 muteins, two-hybrid systems comprising interacting bcl-2-related polypeptide sequences, and uses thereof.

Facts

Application

08/927,326Filed 11 Sep 1997 · division

Priority

26 Aug 1993

Granted

6 Feb 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 14/82
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: translation products from oncogenes
A61P 35/00
Antineoplastic agents
C07K 14/4747
Not used: apoptosis related proteins
A01K 2217/05
Genetically modified animals: animals comprising random inserted nucleic acids

Family

Application08/112,208Parent of this continuation-in-part · filed 26 Aug 1993

Application08/248,819Parent of this continuation-in-part · filed 25 May 1994

Application08/337,646Parent of this division · filed 10 Nov 1994

US 5,856,171 AParent of this division

Application08/337,646Parent of this continuation-in-part

US 5,700,638 AParent of this continuation-in-part

US 5,691,179 AParent of this continuation-in-part

US 6,184,202 B2This patent

From the US filing history. Foreign family members aren’t listed.