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US 6,184,189 B2Granted
Liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
AssigneeAlcon Laboratories, Inc.
InventorsBahram Asgharian, Bor-Shyue Hong
Life of this patent
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Abstract
Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lenses. Methods for a daily use regimen are also disclosed.
Claims31
A stable liquid enzyme composition for cleaning a contact lens comprising:
- an enzyme which is Altrypsin in an amount effective to clean the lens;
- 40-50% w/v of monomeric polyols;
- a borate/boric acid compound in an amount effective to enhance the proteolytic stability of the enzyme;
- calcium ion in an amount effective to enhance the proteolytic stability of the enzyme;
- and water.
2 more elements
A method for cleaning and disinfecting a contact lens comprising:
- placing the lens in an aqueous disinfecting solution containing an amount of an antimicrobial agent effective to disinfect the lens;
- forming an aqueous disinfectant/enzyme solution by dispersing an amount of a liquid enzyme cleaning composition in said disinfecting solution, said cleaning composition comprising:
- an enzyme which is Altrypsin in an amount effective to clean the lens;
- 40-50% w/v of monomeric polyols;
- an effective amount of a borate/boric acid compound in an amount effective to enhance the proteolytic stability of the enzyme;
- calcium ion in an amount effective to enhance the proteolytic stability of the enzyme;
- and water;
- and
- soaking the lens in said aqueous disinfectant/enzyme solution for a period of time sufficient to clean and disinfect the lens.
6 more elements
A method of cleaning a contact lens which comprises:
- forming an aqueous enzymatic cleaning solution by dispersing a small amount of a liquid enzyme composition in an aqueous solvent, said liquid enzyme composition comprising an enzyme in an amount effective to clean the lens;
- 40-50% w/v of monomeric polyols;
- a borate/boric acid compound in an amount effective to enhance the proteolytic stability of the enzyme;
- calcium ion in an amount effective to enhance the proteolytic stability of the enzyme;
- and water;
- and
- soaking the lens in the enzymatic cleaning solution for a period of time sufficient to clean the lens.
4 more elements
Dependencies are inferred from the claim text.