Transport proteins and their uses
AssigneeMarie Curie Cancer Care
InventorsPeter Francis Joseph O'Hare, Gillian Daphne Elliott
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Abstract
The present invention relates to transport proteins, in particular VP22 and homologues thereof, and to methods of delivering these proteins and any associated molecules to a target population of cells. This transport protein has applications in gene therapy and methods of targeting agents to cells where targeting at high efficiency is required.
Claims8
A composition of formula A-B wherein A and B are covalently associated, wherein A comprises a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein, and B comprises a molecule that is desired to be delivered into a cell.
A method of delivering a desired molecule to a population of cells, the method comprising introducing into one or more cells in the population a composition comprising the desired molecule in association with a transport-active material selected from the group consisting of a herpesviral VP22 protein and a transport-active portion of a herpesviral VP22 protein.
Dependencies are inferred from the claim text.