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US 6,184,029 B2Granted
Mesoscale sample preparation device and systems for determination and processing of analytes
AssigneeThe Trustees of the University of Pennsylvania
InventorsPeter Wilding, Larry J. Kricka
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Abstract
A mesoscale sample preparation device capable of providing microvolume test samples, separated into a cell-enriched fraction and a fraction of reduced cell content, for performing various analyses, such as binding assays, determinations involving polynucleotide amplification and the like. Analytical systems including such devices are also disclosed.
Claims6
A combination, comprising (i) a device for preparing a test sample for analysis, said test sample comprising particulate components, and (ii) an appliance, said device comprising:
- a solid substrate fabricated to include:
- a flow channel having a sample inlet port and an outlet;
- and
- a particulate separator disposed in a sample flow channel between the sample inlet and the sample outlet, the direction of flow being from the inlet to the outlet, an upstream facing portion of the separator defining a separation zone in which said particulate components are collected said appliance comprising:
- a nesting well for receiving the device;
- a flow line disposed in the appliance and positioned to communicate with the inlet port of the flow channel in the device when the device is placed into the nesting well;
- and
- a pump connected to the flow line for conveying fluid through the flow channel in the device.
5 more elements
Dependencies are inferred from the claim text.