Catalytic antibodies against cocaine and methods of using and producing same
AssigneeThe Trustees of Columbia University in the City of New York
InventorsDonald W. Landry, Kang Zhao
Life of this patent
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Abstract
This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmaceutical composition for decreasing concentration in a subject using the antibodies produced.
Claims20
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein each of R1, R2, R3, or R4 is independently hydrogen, or a lower alkyl;
- or wherein one but only one of R1, R2, or R3, is a lower alkyl substituted on the terminal carbon atom by an azido or amino group, a group comprising a lower alkyl group linked to a lower carboxylic acid or carboxylic acid derivative, wherein the carboxylic acid derivative is an amide or ester, with each of the remaining two of R1, R2, or R3 is independently hydrogen or a lower alykl and R4 is hydrogen, a lower alkyl or a negative charge.
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein R is a
- or other 5 or 6 membered aromatic ring.
An antibody capable of binding a transition state analog for the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of catalyzing the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein each of R1, R2, R3, or R4 is independently hydrogen, or a lower alkyl;
- or wherein one but only one of R1, R2, R3, is a lower alkyl substituted on the terminal carbon atom by an azido or amino group, a group comprising a lower alkyl group linked to a lower carboxylic acid or carboxylic acid derivative, wherein the carboxylic acid derivative is an aide or ester, with each of the remaining two of R1, R2, R3 is independently hydrogen or a lower alykl and R4 is hydrogen, a lower alkyl or a negative charge.
An antibody capable of catalyzing the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of catalyzing the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of catalyzing the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein X is a primary amine of a carrier protein.
An antibody capable of catalyzing the hydrolysis of cocaine benzoyl ester group and directed against the compound having the structure:
- wherein R is a
- or other 5 or 6 membered aromatic ring.
Dependencies are inferred from the claim text.