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AssigneeDegussa-Huls AG
InventorsMechthild Rieping, Georg Thierbach, Walter Pfefferle, Nicole Dusch, Jorn Kalinowski, Alfred Puhler
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A method for the production of D-pantothenic acid by the fermentation of microorganisms of the family Enterobacteriacae producing D-pantothenic acid which is characterized in that strains are used which a) Contain the plasmid pFV31 and/or pFV202 and that b) A panD gene and optionally other nucleotide sequences coding for aspartate-1-decarboxylase are enhanced, especially overexpressed in these microorganisms, c) The pantothenic acid is enriched in the medium or in the cells of the microorganisms and d) The pantothenic acid formed is isolated.
A method for the production of pantothenic acid comprising:
A microorganism of the species E. coli which contains the plasmid pFV31 and/or pFV202 and which is transformed with a vector comprising a nucleotide sequence encoding the panD gene product, which is aspartate-1-decarboxylase, whose amino acid sequence is set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.