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US 6,184,004 B2Granted
Process for the preparation of galanthamine and its derivatives
AssigneeJanssen Pharmaceutica NV
InventorsRobin Mark Bannister, Raymond McCague
Life of this patent
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Abstract
The subject invention pertains to a process for preparing a compound having a formula (4) or (5), in either optically-enriched or racemic form, wherein R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, aryl, alkaryl, aralkyl and acyl groups. In one embodiment, the process of the invention comprises mixing with a plant extract obtained from crushed daffodil bulbs or crushed snowdrop bulbs an oxidative cyclisation precursor of the compound.
Claims7
A process for producing a compound having a formula (4) or (5)
- comprising:
- a) mixing an effective amount of a crude plant extract obtained from crushed daffodil bulbs or crushed snowdrop bulbs with an effective amount of an amine having a formula (3)
- in a suitable liquid medium for a sufficient time to produce said compound, and
- b) recovering said compound,
- wherein R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, alkyl, aryl, alkaryl, aralkyl, and acyl groups.
2 more elements
Dependencies are inferred from the claim text.