Leukocyte-specific protein and gene, and methods of use thereof
AssigneeThe General Hospital Corporation
InventorsDonald B. Bloch, Kenneth D. Bloch
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Abstract
The present invention is directed to a leukocyte-specific gene Sp140 and its associated protein. Since it has structural analogies to other regulatory proteins and is localized in the nuclear body of certain cell types, Sp140 may be a transcription regulator involved in the body's interaction with viruses and in promyelocytic leukemia. The Sp140 gene can be used in gene therapy for treating certain viral diseases, autoimmune disorders and cancers, while the Sp140 protein may be useful as a diagnostic and prognostic marker in the analysis of certain autoimmune disorders.
Claims7
An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of:
- (a) the nucleotide sequence set forth in SEQ ID NO:1;
- and
- (b) a nucleotide sequence encoding the Sp140 polypeptide having the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.