OspA DNA and lyme disease vaccine

An isolated DNA molecule consisting of a nucleotide fragment encoding OspA protein.

An isolated DNA molecule comprising a nucleic acid sequence encoding an immunogenic fragment of an ospA protein encoded by the nucleotide sequence set forth in FIG. 5.

An isolated DNA molecule consisting essentially of a nucleic acid sequence encoding substantially pure OspA protein of Borrelia burgdorferi.

A Lyme disease vaccine comprising a pharmaceutically acceptable carrier and a viral vector containing DNA encoding substantially pure OspA protein of Borrelia burgdorferi, or an immunogenic fragment thereof, whereby said viral vector expresses substantially pure OspA protein of Borrelia burgdorferi or an immunogenic fragment thereof, and does not express other Borrelia proteins.

A Lyme disease vaccine comprising a pharmaceutically acceptable carrier and a viral vector;

• said vector consisting essentially of DNA encoding substantially pure OspA protein of Borrelia burgdorferi, or an immunogenic fragment thereof, whereby said viral vector expresses substantially pure OspA protein of Borrelia burgdorferi or an immunogenic fragment thereof.